Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
RayzeBio, Inc.
Study ID
NCT07165132
Phase
PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • RYZ401 — DRUG
    Ac-225

Study Details

The primary objectives are to determine the recommended Phase 2 dose (RP2D) and optimal treatment regimen, characterize safety and tolerability, and evaluate preliminary efficacy of RYZ401 in subjects with NETs and other selected solid tumors expressing SSTRs.

Key Dates

First listed
Sep 10, 2025
Start date
Dec 3, 2025
Status verified
Sep 2026
Primary completion
Feb 28, 2027
Completion
Apr 30, 2033

Study Design

Enrollment
104 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Escalation, Dose Expansion

Primary Outcome Measure

Dose Escalation [ Time Frame: Incidence of DLTs during the first 4 weeks of RYZ401 treatment ]

Central Contacts

Locations (12)

FacilityCityStateZIPSite coordinators
Research FacilityPhoenixArizona85054-
Research FacilityJacksonvilleFlorida32224-
Research FacilityIowa CityIowa52242-
Research FacilityLexingtonKentucky40536-
Research FacilityRochesterMinnesota55905-
Research FacilitySt LouisMissouri63104-
Research FacilitySt LouisMissouri63110-
Research FacilityColumbusOhio43210-
Research FacilityPortlandOregon97239-
Research FacilityNashvilleTennessee37232-
Research FacilitySalt Lake CityUtah84112-
Research FacilityCharlottesvilleVirginia22903-

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