The Progressive Supranuclear Palsy Clinical Trial Platform

Part of paid clinical trials in Palo Alto, California.

Sponsor
Adam Boxer
Study ID
NCT07173803
Phase
PHASE2
Status
Recruiting
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Conditions

  • Progressive Supranuclear Palsy(PSP)

Eligibility Criteria

Sex
ALL
Age
41 Years - 86 Years
Healthy Volunteers
Not accepted

Interventions

  • AADvac1 — BIOLOGICAL
    Active immunotherapy
  • LM11A-31 — DRUG
    Small molecule

Study Details

The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) is a multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of PSP.

Key Dates

First listed
Sep 15, 2025
Start date
Jul 29, 2026
Status verified
Nov 2025
Primary completion
Sep 28, 2030
Completion
Sep 28, 2030

Study Design

Enrollment
440 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Regimen A: AADvac1
    Participants are randomized to receive either active AADvac1 or matching placebo.
  • Experimental: Regimen B: LM11A-31
    Participants are randomized to receive either active LM11A-31 or matching placebo.

Primary Outcome Measure

Disease progression [ Time Frame: 52 weeks ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Stanford UniversityPalo AltoCalifornia94304
Niyatee Samudra, MD (PRINCIPAL_INVESTIGATOR)
University of California, San DiegoSan DiegoCalifornia92093
Katherine Longardner, MD (PRINCIPAL_INVESTIGATOR)
University of California, San FranciscoSan FranciscoCalifornia94158
Julio Rojas-Martinez, MD, PhD (PRINCIPAL_INVESTIGATOR)
Massachusetts General HospitalBostonMassachusetts02114
Catherine Isroff, MD (PRINCIPAL_INVESTIGATOR)
Albany Medical CollegeAlbanyNew York12208
Octavian Adam, MD (PRINCIPAL_INVESTIGATOR)
Butler HospitalProvidenceRhode Island02906
Edward Huey, MD (PRINCIPAL_INVESTIGATOR)
Houston MethodistHoustonTexas77030
Joseph Masdeu, MD, PhD (PRINCIPAL_INVESTIGATOR)
University of WashingtonSeattleWashington98195
Michael Rosenbloom, MD, FAAN (PRINCIPAL_INVESTIGATOR)

Find similar trials in Palo Alto, CA

By research site
Stanford University· Palo Alto, CAUniversity of California, San Diego· San Diego, CAUniversity of California, San Francisco· San Francisco, CAMassachusetts General Hospital· Boston, MAAlbany Medical College· Albany, NYButler Hospital· Providence, RI

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