Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults

Sponsor
Queen's University
Study ID
NCT07178353
Status
Recruiting
Apply to this trial

Conditions

  • Insulin Resistance
  • Muscle Protein Synthesis
  • Muscular Atrophy

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Bedrest — OTHER
    5 days of strict bedrest. Participants are allowed to sit up in bed, but will perform any bathing or bathroom activities in a wheelchair.

Study Details

The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are: How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest? Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest: * Magnetic resonance imaging of the thigh muscles * Strength testing of the thigh muscles * Insulin sensitivity testing in response to a mixed meal * Exogenous glucose oxidation in response to a mixed meal * Muscle biopsies from the thigh muscles * Blood samples

Key Dates

First listed
Sep 17, 2025
Start date
Sep 30, 2025
Status verified
Sep 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental: Bedrest
    19 day study period, consisting of baseline testing, 5 days of free-living (habitual daily activities) immediately followed by 5 days of strict bedrest. Diet controlled and physical activity monitored for entire study period.

Primary Outcome Measure

Quadriceps muscle volume [ Time Frame: Day 0, and 5 ]

Central Contacts

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