The Metabolic and Genetic Drivers of Body Composition Changes Following Weight Loss Surgery

Part of paid clinical trials in Galveston, Texas.

Sponsor
The University of Texas Medical Branch, Galveston
Study ID
NCT07178704
Status
Recruiting
Apply to this trial

Conditions

  • Bariatric Surgery Patients

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Study Details

Weight loss surgery is very good at reducing body weight but it can also cause the loss of both muscle and strength. Some patients undergoing weight loss surgery do not achieve their weight loss goals and regain the weight they lost. When this occurs, the loss of muscle and strength combined with the regain of weight can impact the individual's quality of life and ability to remain active and mobile. The purpose of this study is to understand the behavioral, biological, and genetic factors that influence the success of weight loss surgery and its impact on muscle mass. Bariatric surgery patients participating in the trial will be monitored prior to, and for a year following weight loss surgery, with data collected about their eating habits, hand grip strength, and the loss of fat, muscle, and body weight following surgery. In patients who undergo a routine endoscopy in advance of weight loss surgery a small sample of gut tissue will be collected to identify the expression (activity) of genes in their DNA.

Key Dates

First listed
Sep 17, 2025
Start date
Nov 4, 2025
Status verified
Jul 2026
Primary completion
Feb 28, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Bariatric Surgery Patients
    Patients due to undergo either sleeve gastrectomy or gastric bypass surgery.

Primary Outcome Measure

Body composition [ Time Frame: Measured at baseline in both healthy volunteers & bariatric surgery patients undergoing metabolic assessment. The latter will undergo repeat assessment on two further occasions across a 1 year period post surgery. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas Medical BranchGalvestonTexas77555
Emily J Lantz, PhD
[email protected]
409-772-0643
Emily J Lantz, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
The University of Texas Medical Branch· Galveston, TX

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