Echocardiographic Assessment of Pulmonary Hypertension in Obstructive Sleep Apnea

Sponsor
Assiut University
Study ID
NCT07184060
Status
Not Yet Recruiting

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Conditions

  • Obstructive Sleep Apnea (OSA)
  • Pulmonary Hypertension

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Study Details

This study investigates the association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), focusing on the relationship between OSA severity and pulmonary arterial pressures in adult patients.

Key Dates

First listed
Sep 19, 2025
Start date
Oct 30, 2025
Status verified
Sep 2025
Primary completion
Apr 30, 2027
Completion
Aug 30, 2027

Study Design

Enrollment
55 participants (estimated)

Arms

  • Arm: adult patients with confirmed OSA
    Eligible participants are 18-65 years old and diagnosed with OSA (AHI ≥ 5 events/hour) confirmed through full-night polysomnographic sleep study. Patients will be stratified into mild (AHI 5-14), moderate (AHI 15-29), and severe OSA (AHI ≥ 30). Exclusion criteria include patients with secondary PH (from cardiac causes, chronic thromboembolic disease, or pulmonary conditions), chronic vasodilator therapy, long-term oxygen therapy, advanced organ failure, neuromuscular or chest wall deformities, obesity hypoventilation syndrome, or malignancy. The expected sample size is 55 patients, ensuring enough statistical power to detect associations. Demographic, clinical, echocardiographic, radiological, and sleep study parameters will be collected for each patient.

Primary Outcome Measure

Mean Pulmonary Artery Pressure [ Time Frame: baseline ]

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