Clinical, Radiological, Tissue and Biological Phenotyping for the Analysis of the Transition From Physiology to Pathology in Pulmonary Diseases With Pulmonary Hypertension

Sponsor
Assistance Publique Hopitaux De Marseille
Study ID
NCT07184671
Status
Not Yet Recruiting

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Conditions

  • Chronic Pulmonary Disease
  • Pulmonary Hypertension

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • blood sampling — BIOLOGICAL
    22mL peripheral blood will be collected
  • broncho-alveolar lavage sampling — BIOLOGICAL
    Collected on resected tissue
  • lung parenchyma sampling — BIOLOGICAL
    Collected on resected tissue

Study Details

This is a monocentric, case-control, comparative study aiming at investigating the transition from physiological to pathological pulmonary circulation in patients with pulmonary hypertension (PH) and chronic lung diseases. The study will include 105 adults participants undergoing lung surgery, divided into three groups, Group A (patients with chronic lung disease and PH undergoing lung transplantation), Group B (patients with chronic lung disease without PH), and Group C (patients without chronic lung disease nor PH). The primary objective is to identify the association between vascular remodeling and PH by measuring the medial thickness of pulmonary arteries. Secondary objectives include multimodal phenotyping (clinical, radiological, tissue, and biological) to explore mechanisms of PH development. Blood, broncho-alveolar lavage, and lung tissue samples will be collected during routine care. The study aims to improve understanding of PH pathophysiology and identify potential biomarkers and therapeutic targets.

Key Dates

First listed
Sep 22, 2025
Start date
Sep 30, 2025
Status verified
Sep 2025
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
105 participants (estimated)

Arms

  • Arm: Patients with chronic pulmonary disease and pulmonary hypertension
    Patients on the lung transplant list with chronic pulmonary disease and pulmonary hypertension
  • Arm: Control patients with chronic pulmonary disease without pulmonary hypertension
    Control patients with chronic pulmonary disease without pulmonary hypertension on the lung transplant list or with an indication for lung resection surgery for diagnostic or therapeutic purposes.
  • Arm: Control patients without chronic pulmonary disease or pulmonary hypertension
    Control patients without chronic pulmonary disease or pulmonary hypertension with an indication for lung resection.

Primary Outcome Measure

Percentage of pulmonary artery media thickness measured by optical microscopy [ Time Frame: Surgical intervention ]

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