Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance.

Sponsor
London North West Healthcare NHS Trust
Study ID
NCT07208214
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • TXI — DIAGNOSTIC_TEST
    Participants allocated to the "TXI" group undergo withdrawal using Texture and Colour Enhancement Imaging, while those in the "Dye" group receive withdrawal with Dye chromoendoscopy. Both procedures follow standardized protocols outlined in the study design.

Study Details

In individuals with inflammatory bowel disease (IBD), bowel cancer can develop from abnormal cell changes (dysplasia). Regular colonoscopies are recommended to identify these early changes, which can be difficult to detect because they are often small and subtle. Dye-based imaging has been used to improve detection, but it requires additional preparation and time. Texture and Colour Enhancement Imaging (TXI) is a newer method available in clinical practice that adjusts brightness, colour, and texture on high-definition cameras. This study will compare TXI with dye-based imaging to assess which approach detects precancerous changes more effectively in patients with IBD.

Key Dates

Start date
Oct 1, 2025
Status verified
Sep 2025
Primary completion
Jul 1, 2027
Completion
Jul 1, 2027

Study Design

Enrollment
242 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Active Comparator: TXI
    Participants allocated to the "TXI" group undergo withdrawal using Texture and Colour Enhancement Imaging
  • Other: Dye
    Participants allocated in the "Dye" group receive withdrawal with Dye chromoendoscopy.

Primary Outcome Measure

To compare the proportion of patients with at least 1 dysplastic lesion detected using TXI compared with dye chromoendoscopy [ Time Frame: 6 months ]

Central Contacts

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