Improving Neurological Health With Acetylcholine Via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment

Sponsor
Posit Science Corporation
Study ID
NCT07243600
Status
Recruiting
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Conditions

  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Computerized speed-based cognitive training — OTHER
    Thirty minutes of training on computerized exercises that targets visual processing speed, memory, attention and alertness.
  • Computerized executive function cognitive training — OTHER
    Thirty minutes of training on computerized exercises that target executive function.

Study Details

This study is a validation study to evaluate efficacy of two neuroplasticity-based, computerized cognitive training programs to improve neurological and neuropsychological health in older adults with mild cognitive impairment (MCI).

Key Dates

First listed
Nov 24, 2025
Start date
Jul 17, 2026
Status verified
Jul 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
84 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Speed Training
    Computerized speed-based cognitive training requiring a total maximum of 70 treatment sessions, up to 7 sessions per week, 30 minutes per session.
  • Active Comparator: Executive Function Training
    Computerized executive function cognitive training requiring a total maximum of 70 treatment sessions, up to 7 sessions per week, 30 minutes per session.

Primary Outcome Measure

Change in Global cholinergic signaling using [18F]fluoroethoxybenzovesamicol (FEOBV) positron-emission tomography (PET) [ Time Frame: at 3 months (post-intervention) ]

Central Contacts

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