Escitalopram Plasma Concentrations in Premenopausal and Postmenopausal Women

Sponsor
Eskisehir Osmangazi University
Study ID
NCT07259525
Status
Not Yet Recruiting

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Conditions

  • Depression - Major Depressive Disorder
  • General Anxiety Disorder
  • Menopause
  • Therapeutic Drug Monitoring (TDM)

Eligibility Criteria

Sex
FEMALE
Age
40 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

This observational cross-sectional case-control study aims to evaluate the effects of menopausal status on escitalopram metabolism in women. The study will include premenopausal and menopausal women aged 40-60 years who are currently receiving escitalopram treatment and have applied to the Psychiatry Clinic of Eskişehir Osmangazi University. The study aims to identify pharmacokinetic differences associated with hormonal status and to investigate their potential clinical implications. Findings from this research are expected to contribute to the development of evidence-based, individualized treatment strategies for women in menopausal transition.

Key Dates

First listed
Dec 2, 2025
Start date
Jan 31, 2026
Status verified
Dec 2025
Primary completion
Jan 31, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
94 participants (estimated)

Arms

  • Arm: Premenopausal Women
    Women aged 40-60 years, premenopausal, diagnosed with major depressive disorder and/or generalized anxiety disorder, and currently receiving escitalopram treatment.
  • Arm: Postmenopausal Women
    Women aged 40-60 years, postmenopausal, diagnosed with major depressive disorder and/or generalized anxiety disorder, and currently receiving escitalopram treatment.

Primary Outcome Measure

Dose-Related Plasma Escitalopram Concentrations [ Time Frame: Up to 14 days ]

Central Contacts

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