Association Between Vitamin D Deficiency and Inflammatory Bowel Disease

Sponsor
Assiut University
Study ID
NCT07259603
Status
Not Yet Recruiting

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Conditions

  • Inflammatory Bowel Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate — DIAGNOSTIC_TEST
    Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate are evaluated to assess vitamin D deficiency and IBD activity

Study Details

Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods. In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD. Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D. Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported. Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases. In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence. In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D

Key Dates

First listed
Dec 2, 2025
Start date
Jan 31, 2026
Status verified
Nov 2025
Primary completion
Jan 31, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: patients diagnosed with Crohn's disease (CD) and ulcerative colitis (UC)
    Adults aged ≥18 years, diagnosed with Crohn's disease (CD) and ulcerative colitis (UC), and on regular follow-up in the IBD clinic, are followed up for recent vitamin D and disease activity assessment (within 1 month)

Primary Outcome Measure

Prevalence of vitamin D deficiency in patients with active inflammatory bowel disease [ Time Frame: Recent vitamin D and disease activity assessment (within 1 month) ]

Central Contacts

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