Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT07265505
Status
Not Yet Recruiting

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Conditions

  • Adenomyosis
  • Endometrial Diseases
  • Endometriosis
  • Endometritis
  • Infertility, Female
  • Recurrent Implantation Failure
  • Recurrent Pregnancy Loss

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 35 Years
Healthy Volunteers
Not accepted

Interventions

  • Endometrial Biopsy — DIAGNOSTIC_TEST
    Endometrial biopsy with Cornier Pipelle (part of the treatment in the RIF/RPL group and some patients of the control group / added for the research for the other patients of the control group)
  • Vaginal Swab — DIAGNOSTIC_TEST
    Vaginal sample collection using a cotton swab. Part of the treatment
  • Blood sample — DIAGNOSTIC_TEST
    Peripheral blood draw. Part of the treatment + 10 mL additional for research
  • Pelvic ultrasound (±pelvic MRI) — DIAGNOSTIC_TEST
    Pelvic ultrasound (±pelvic MRI). Part of the treatment

Study Details

The IMERR study aims to improve understanding of certain causes of infertility related to recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL), conditions that affect many women undergoing assisted reproductive technology (ART). Despite medical advances, some patients repeatedly fail to achieve pregnancy, or experience repeated miscarriages. These situations may be linked to subtle immune or microbial disturbances in the uterus. This study seeks to identify immune and microbiological profiles in the endometrium during the implantation window-a crucial period when the embryo attaches to the uterine wall. We will compare women who have experienced RIF and/or RPL with women who have had no such history. Blood and uterine samples will be analyzed to investigate whether certain immune or microbial features are associated with these reproductive failures. The ultimate goal is to uncover predictive factors that may explain why some women experience implantation failure or pregnancy loss, and to lay the foundation for future personalized treatments to improve reproductive outcomes.

Key Dates

First listed
Dec 4, 2025
Start date
Apr 30, 2026
Status verified
Feb 2026
Primary completion
Apr 30, 2029
Completion
Apr 30, 2031

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Other: RIF/RPL group
    Women undergoing ART with a history of recurrent implantation failure (RIF) and/or recurrent pregnancy loss (RPL).
  • Other: Control group
    Women undergoing ART without a history of RIF or RPL.

Primary Outcome Measure

Profiling of endometrial immune cell populations [ Time Frame: Baseline ]

Central Contacts

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