Effects of Vagus Nerve Stimulation on Temporomandibular Disorders.

Part of paid clinical trials in Los Angeles, California.

Sponsor
Arpana Church
Study ID
NCT07288411
Status
Recruiting
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Conditions

  • TMD
  • Temporomandibular Disorders (TMDs)

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • nVNS Treatment — DEVICE
    nVNS treatment 2x/week for 8 consecutive weeks.

Study Details

The study aims to examine the effects of transcutaneous non-invasive vagus nerve stimulation (nVNS) on symptoms and brain mechanisms in premenopausal women with temporomandibular disorders (TMD). Non-invasive vagus nerve stimulation (nVNS) is the most well researched and possibly the most effective non-invasive neuromodulation treatment for chronic pain conditions that targets the brain-gut-microbiome (BGM) axis. Participants will be asked to come in for 2 in-clinic visits, at baseline and post treatment. Participants will also be asked to come in 2x/week for 8 consecutive weeks to receive the nVNS treatment. The in-clinic visits will include physical measures, blood draw, saliva sample, and brain MRI. Participants will be asked to collect a stool sample at home and answer online questionnaires regarding, mood, pain, and health behaviors at home, prior to the in-clinic appointments.

Key Dates

First listed
Dec 17, 2025
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Active nVNS Treatment
    nVNS Treatment 2x/week for 8 weeks

Primary Outcome Measure

Pain Intensity [ Time Frame: From the baseline in-clinic visit through 8 weeks of biweekly visits, assessed immediately before and after each nVNS session. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095-

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University of California, Los Angeles· Los Angeles, CA

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