Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in Prediabetes

Sponsor
The First Affiliated Hospital of Guangdong Pharmaceutical University
Study ID
NCT07289880
Status
Not Yet Recruiting

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Conditions

  • Prediabetes

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Diacylglycerol oil — COMBINATION_PRODUCT
    This study will implement a four-week dietary intervention in which participants assigned to the intervention group will replace their habitual cooking oil with diacylglycerol (DAG) oil. All other lifestyle behaviors will be maintained without modification.
  • Colza Oil — COMBINATION_PRODUCT
    Participants assigned to the control group will consume colza oil as their cooking oil throughout a four-week dietary intervention. No other lifestyle habits or dietary behaviors will be altered.

Study Details

This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil, while those in the control arm will consume colza oil. All other lifestyle behaviors will be maintained without modification. The trial will determine the impact of DAG oil consumption on glycemic regulation, lipid metabolism, and body composition in this high-risk population.

Key Dates

First listed
Dec 17, 2025
Start date
Dec 30, 2025
Status verified
Dec 2025
Primary completion
Dec 1, 2026
Completion
Dec 30, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: DAG Oil Group
    A four-week dietary intervention will be implemented, during which participants assigned to the intervention group will replace their habitual cooking oil with diacylglycerol (DAG) oil.
  • Active Comparator: Control Group
    Participants assigned to the control group will consume colza oil as their cooking oil throughout a four-week dietary intervention. No other lifestyle habits or dietary behaviors will be altered.

Primary Outcome Measure

Continuous Glucose Monitoring (CGM) Data [ Time Frame: up to 4 weeks ]

Central Contacts

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