PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
Part of paid clinical trials in Scottsdale, Arizona.
- Sponsor
- Northwestern University
- Study ID
- NCT07293689
- Status
- Recruiting
Conditions
- Distal Esophageal Spasm
- EGJ Outflow Obstruction With Spastic/Hypercontractile Features
- Jackhammer Esophagus
- Type III Achalasia
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Study Details
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions. The main question it aims to answer is: does pre-POEM testing help the physician choose how long to cut the muscle. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Key Dates
- First listed
- Dec 19, 2025
- Start date
- Dec 1, 2026
- Status verified
- Aug 2026
- Primary completion
- Aug 31, 2031
- Completion
- Aug 31, 2032
Study Design
- Enrollment
- 200 participants (estimated)
Primary Outcome Measure
Clinical Response-Overall [ Time Frame: From enrollment to Year 2 ]
Central Contacts
- Elizabeth Yan, BS312-908-1723
- Yasmin Pina, BS312-503-6459
Locations (16)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | - |
| University of California San Diego | La Jolla | California | 92093 | - |
| University of Colorado Denver | Denver | Colorado | 80217 | - |
| University of Florida | Gainesville | Florida | 32611 | Peter Draganov, MD (PRINCIPAL_INVESTIGATOR) |
| Adventist Health System/Sunbelt, Inc | Orlando | Florida | 32803 | - |
| Emory University | Atlanta | Georgia | 30322 | Anand Jain, MD (PRINCIPAL_INVESTIGATOR) |
| Northwestern University | Chicago | Illinois | 60611 | John Pandolfino, MD (PRINCIPAL_INVESTIGATOR) |
| Johns Hopkins University | Baltimore | Maryland | 21218 | - |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Kyle Staller, MD (PRINCIPAL_INVESTIGATOR) |
| Washington University | St Louis | Missouri | 63130 | - |
| Weill Cornell Medical College | New York | New York | 10065 | - |
| Atrium Health/Wake Forest | Charlotte | North Carolina | 28204 | Badih Elmunzer, MD (PRINCIPAL_INVESTIGATOR) |
| Case Western Reserve University | Cleveland | Ohio | 44106 | - |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | Ronnie Fass, MD (PRINCIPAL_INVESTIGATOR) |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Dhyanesh Patel, MD (PRINCIPAL_INVESTIGATOR) |
| Baylor Scott & White Health | Dallas | Texas | 75204 | - |