Deep Brain Stimulation of the Anterior Cingulate Bundle (ACB) and the Ventral Anterior Limb of the Internal Capsule (vALIC) in Patients With Intractable Obsessive Compulsive Disorder (OCD)

Sponsor
Rhode Island Hospital
Study ID
NCT07303946
Status
Not Yet Recruiting

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Conditions

  • Obsessive-Compulsive Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Medtronic Percept system and 3391 3387 Medtronic DBS electrodes — DEVICE
    Surgical implantation of deep brain stimulation electrodes with stimulation at one of two intracranial targets depending on randomization and crossover status.

Study Details

This is a double blind pilot feasibility study, with a within subject crossover design of DBS of the anterior cingulate bundle(ACB) and the ventral anterior limb of the internal capsule(vALIC) in four patients with intractable OCD. Patients will be screened according to inclusion exclusion criteria listed above, approved by an independent Neuropsychiatric review board and informed consent obtained.

Key Dates

First listed
Dec 26, 2025
Start date
Jan 31, 2026
Status verified
Dec 2025
Primary completion
Jan 31, 2030
Completion
Jan 31, 2031

Study Design

Enrollment
4 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: ACB
    DBS of the anterior cingulate bundle (ACB)
  • Experimental: vALIC arms
    DBS of the ventral anterior limb of the internal capsule (vALIC)

Primary Outcome Measure

Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) [ Time Frame: At the final visit of Stage 1, which occurs at the end of 12 weeks of active stimulation of the first target. ]

Central Contacts

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