Predicting the Pain Outcome of Surgery for Endometriosis

Sponsor
University of Oxford
Study ID
NCT07313345
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Surgical treatment of endometriosis — PROCEDURE
    This is an observational study and thus the surgery performed is part of standard clinical care. The procedure will be at the discretion of the operating surgeon/endometriosis multi-disciplinary team and may include bowel resection, stoma formation, ureteric stenting/reimplantation, salpingectomy, oophorectomy or hysterectomy in addition to excision/ablation of endometriosis lesions. Information about the surgical procedure will be collected, but no planned surgical procedure will be an exclusion.

Study Details

This study aims to determine whether the investigators can predict who will get benefit in terms of their pain from surgery for more severe forms of endometriosis. The investigators will use brain imaging to explore this, as it allows meaningful results from a smaller sample of people than if questionnaires alone were relied on.

Key Dates

First listed
Dec 31, 2025
Start date
Dec 31, 2025
Status verified
Dec 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: PrePOSE cohort
    Women aged 18 - 50 years, with stage III or IV endometriosis, reporting pelvic pain of ≥4/10 and planned for surgical treatment of their endometriosis

Primary Outcome Measure

Brain response to punctate stimulation of the calf [ Time Frame: prior to surgery ]

Central Contacts

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