Incidence of Myopia in a Prospective Cohort of Emmetropic Children and Associated Ocular and Environmental Factors

Sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Study ID
NCT07316998
Status
Recruiting
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Conditions

  • Myopia

Eligibility Criteria

Sex
ALL
Age
4 Years - 8 Years
Healthy Volunteers
Not accepted

Interventions

  • annual follow-up — OTHER
    annual follow-up including ophtalmologic examination and biometry and behavioural questionnaires

Study Details

Myopia and high myopia are among the leading causes of visual impairment and blindness worldwide. The total number of people with myopia worldwide was estimated at 2.6 billion in 2020 and could reach 4.8 billion by 2050 unless preventive interventions are implemented. Most epidemiological studies have focused on risk factors for myopia progression, with far fewer addressing the factors that cause a child to shift from emmetropia to myopia. The risk factors for the onset of myopia may be the same as those for myopia progression. However, for an equivalent level of risk exposure, it remains unclear why some children develop myopia while others do not. Identifying the population most at risk of developing myopia would make it possible to propose preventive treatments aimed at delaying or preventing its onset. This would allow evaluation of the effectiveness of current myopia control treatments (peripheral defocus lenses, atropine, contact lenses) in preventing the onset of myopia, as well as future targeted treatments, including the potential benefit of early optical correction-a strategy once used but later abandoned due to a lack of robust scientific evidence. The establishment of longitudinal follow-up of young emmetropic children at the French Institute of Myopia will enable the acquisition of high-quality imaging, allowing investigation of the association between advanced imaging parameters and external environmental factors with the onset of myopia.

Key Dates

First listed
Jan 5, 2026
Start date
Feb 18, 2026
Status verified
Jul 2026
Primary completion
Feb 28, 2031
Completion
Feb 28, 2031

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Children aged 4 to 8 years at inclusion, emmetropic (cycloplegic SE 0 to +2D) in each eye d

Primary Outcome Measure

To describe the incidence of myopia over the 2 years following inclusion in emmetropic children. [ Time Frame: Annual follow up : Year 1 and year 2 ]

Central Contacts

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