Photoacoustic/Ultrasound Imaging of Brown Adipose Tissue Activity

Sponsor
Peking Union Medical College Hospital
Study ID
NCT07327684
Status
Recruiting
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Conditions

  • Insulin Resistance
  • Metabolic Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Multi-wavelength PA/US imaging scanning and cold exposure — DEVICE
    Participants will undergo multi-wavelength PAI scans of BAT region under normal conditions and after 30-60 mins cold exposure to assess BAT activation.
  • Multi-wavelength PA/US imaging scanning and cold exposure — DEVICE
    Participants will undergo multi-wavelength PAI scans of BAT region under normal conditions and after 30-60 mins cold exposure to assess BAT activation.

Study Details

The goal of this study is to develop a novel, non-invasive, real-time photoacoustic imaging (PAI) technology for quantifying brown adipose tissue (BAT) and to investigate the differences in BAT morphology and metabolic function between healthy individuals and patients with metabolic syndrome. The main questions it aims to answer are: 1. Can PAI technology quantify BAT metabolic function and establish standardized PAI parameters for BAT assessment? 2. Can PAI parameters distinguish the BAT characteristics of healthy volunteers from patients with metabolic syndrome? Both healthy adults and patients diagnosed with metabolic syndrome will be recruited. Participants will undergo PAI scans of BAT region under normal conditions and after cold exposure to assess BAT activation. The ultimate goal is to validate this radiation-free PAI method as a convenient and effective tool for evaluating BAT metabolism, potentially aiding in early diagnosis and treatment monitoring of metabolic syndrome.

Key Dates

First listed
Jan 8, 2026
Start date
May 22, 2025
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Brown adipose tissue assessment of healthy volunteers based on PA/US imaging
    Establish a non-invasive, real-time PAI method for quantitative characterization of human BAT morphology and metabolic function and evaluate the baseline of BAT PA parameters in healthy population.
  • Experimental: Brown adipose tissue assessment of patients with metabolic syndrome based on PA/US imaging
    Evaluate the BAT PA parameters in patients with metabolic syndrome.

Primary Outcome Measure

Change in photoacoustic imaging (PAI)-derived total hemoglobin concentration within brown adipose tissue (BAT) after cold exposure. [ Time Frame: Baseline and immediately after a standardized 0.5-1 hour cold exposure procedure ]

Central Contacts

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