Predictive Value of the Uric Acid/Albumin Ratio and Lactate in Sepsis Patients

Sponsor
Istinye University
Study ID
NCT07332715
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury
  • Sepsis-Related Mortality

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Non-interventional / Observational Study — OTHER
    This is a non-interventional, observational study. No diagnostic or therapeutic intervention will be applied beyond routine clinical care. Blood uric acid, albumin, and serum lactate levels measured as part of standard intensive care management will be recorded at admission, and lactate levels will be reassessed at 24 hours. Patients will be followed prospectively during their intensive care stay to evaluate the development of acute kidney injury, vasopressor requirement, and 28-day mortality.

Study Details

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units. Early identification of patients at high risk for adverse outcomes is essential for timely intervention and improved prognosis. This prospective, single-center, non-interventional study aims to evaluate the predictive value of the combined use of the blood uric acid/albumin ratio (UAR) and serum lactate levels in patients aged 65 years and older who are admitted to the intensive care unit with a diagnosis of sepsis according to SEPSIS-3 criteria. Patients without acute kidney injury at admission and with at least 24 hours of intensive care follow-up will be included. The primary outcome is the development of acute kidney injury within the first 7 days of ICU admission according to KDIGO criteria. Secondary outcomes include vasopressor requirement during ICU stay, changes in serum lactate levels over the first 24 hours, and 28-day mortality. The study seeks to determine whether the combination of UAR and lactate levels can serve as an easily accessible and clinically applicable biomarker to predict adverse outcomes and support prognostic assessment and treatment strategies in sepsis patients.

Key Dates

First listed
Jan 12, 2026
Start date
Jan 15, 2026
Status verified
Jan 2026
Primary completion
May 15, 2026
Completion
May 31, 2026

Study Design

Enrollment
80 participants (estimated)

Primary Outcome Measure

Development of Acute Kidney Injury (AKI) [ Time Frame: Within the first 7 days following intensive care unit admission ]

Central Contacts

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