Amylin-Induced Migraine Attacks Without Aura

Sponsor
Danish Headache Center
Study ID
NCT07340788
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Amino Acids, Peptides, and Proteins
  • Amylin
  • Brain Diseases
  • Central Nervous System Diseases
  • Headache
  • Headache Disorders
  • Headache Disorders, Primary
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Migraine Disorders
  • Nervous System Diseases
  • Neurologic Manifestations
  • Pain
  • Pathological Conditions, Signs and Symptoms
  • Peptide Hormones
  • Peptides
  • Pramlintide
  • Signs and Symptoms

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Amylin — DRUG
    The participants will receive continuous intravenous infusion of 20 mL (6 μg/min) of pramlintide (amylin) over 20 minutes.
  • Placebo — DRUG
    The participants will receive continuous intravenous infusion of 20 mL of placebo (isotonic saline) over 20 minutes.

Study Details

Pramlintide is a peptide analogue of human amylin which is a vasoactive signaling molecule involved in the pathogenesis of migraine. This study investigates whether pramlintide induces migraine attacks without aura in people with migraine without aura.

Key Dates

First listed
Jan 14, 2026
Start date
Feb 28, 2026
Status verified
Jan 2026
Primary completion
Oct 30, 2028
Completion
Oct 30, 2028

Study Design

Enrollment
21 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Amylin
    Pramlintide (Amylin) will be administered by intravenous infusion.
  • Placebo Comparator: Placebo
    Placebo (isotonic saline) will be administered by intravenous infusion.

Primary Outcome Measure

Incidence of migraine attacks without aura [ Time Frame: 12 hours ]

Central Contacts

Related Studies