Dynamic 82-Rb Positron Emission Tomography (PET) for the Grading of KIDney Carcinoma

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT07346404
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • 82-Rb injection — DRUG
    Injection of 82-Rb for 82-Rb PET imaging

Study Details

This is a pilot prospective longitudinal monocentric, non-comparative, nonrandomised, and non-controlled open study. is to test whether the intensity of 82-Rb uptake on PET acquisitions is associated to the aggressiveness of RCC on histology (ISUP grades), i.e., to successfully identify high-grade (ISUP grades 3 and 4) vs. lowgrade (ISUP grades 1 and 2) RCC.

Key Dates

First listed
Jan 16, 2026
Start date
Jan 1, 2026
Status verified
Dec 2025
Primary completion
Jan 1, 2028
Completion
Jan 1, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Other: 82-Rubidium
    82-Rb; 10 MBq/kg intravenous injection over 30-60 seconds using an automated injection; two injections (Minimal injected activity per injection: 740 MBq ; maximal injected activity per injection: 1480 MBq).

Primary Outcome Measure

Classify the aggressiveness of RCC into low grade and high grade based on the 82-Rb uptake intensity in renal tumors on PET. [ Time Frame: Up to three months after surgery ]

Central Contacts

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