Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

Sponsor
Uppsala University
Study ID
NCT07351149
Status
Recruiting
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Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
0 Years - 16 Years
Healthy Volunteers
Not accepted

Study Details

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

Key Dates

First listed
Jan 20, 2026
Start date
Mar 1, 2026
Status verified
May 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
2,000 participants (estimated)

Arms

  • Arm: Children undergoing major non-cardiac surgery under general anaesthesia
    Eligible participants are children aged 0-16 years admitted for non-ambulatory, non-cardiac major surgery requiring general anaesthesia with an estimated duration of at least 60 minutes, including elective, urgent, and emergency procedures. Non-ambulatory surgery is defined as a planned overnight hospital admission following the procedure.

Primary Outcome Measure

Incidence of postoperative AKI [ Time Frame: Within 7 postoperative days ]

Central Contacts

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