Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

Sponsor
Institut Pasteur du Cambodge
Study ID
NCT07358910
Status
Recruiting
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Conditions

  • Adenovirus
  • Arenavirus Infections
  • Ascaris Lumbricoides
  • Brucellosis
  • Chikungunya
  • Chlamydia
  • Clonorchis Sinensis
  • Cytomegalovirus
  • Dengue
  • Diphteria
  • Entamoeba Histolytica
  • Enterovirus
  • Epstein Barr Virus
  • Giardiasis
  • Hantavirus Infections
  • Hepatitis A
  • Hepatitis E
  • Human Papilloma Virus (HPV)
  • Influenza A and B
  • Japanese Encephalitis
  • Legionella Pneumophila Pneumonia
  • Leishmaniasis
  • Leptospirosis
  • Lymphatic Filariasis
  • Malaria
  • Mayaro Fever
  • Measles
  • Melioidosis
  • Meningitis
  • Mumps
  • Mycoplasma
  • Nipah Virus Infection
  • Norovirus Infections
  • Opisthorchis Viverrini
  • Oropouche Fever
  • Parvovirus
  • Pertussis
  • Q Fever
  • Respiratory Syncytial Virus (RSV)
  • Rhinovirus
  • Rift Valley Fever
  • Rotavirus Disease
  • Rubella
  • Salmonella Typhi
  • Schistosomiasis
  • Severe Fever With Thrombocytopenia Syndrome
  • Streptococcus Pneumoniae
  • Strongyloides Stercoralis Infection
  • Tetanus
  • Tick-borne Encephalitis (TBE)
  • Toxoplasma Gondii
  • Trichuris Trichiura
  • Usutu Virus Infection
  • Varicella
  • Vibrio Cholerae
  • West Nile Virus
  • Yellow Fever
  • Zika Virus Infection

Eligibility Criteria

Sex
ALL
Age
2 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics. This knowledge gap hinders the design of effective prevention and control strategies. RACSMEI will improve understanding across multiple pathogens using a multidisciplinary One Health approach. We will answer key questions on burden, ecology, transmission and population immune status to inform targeted and culturally appropriate interventions. The project combines a nationally representative One Health survey, social-science methods, and multiplex, diverse diagnostics to efficiently test for 57 priority pathogens, including zoonotic and vector-borne agents, vaccine-preventable and elimination-targeted diseases, enteric, respiratory, and environmentally transmitted pathogens and selected neglected tropical diseases and parasites relevant to Cambodia. Mathematical modelling will reconstruct and forecast transmission dynamics and assess the potential impact of future public-health strategies. By integrating intersectoral data and innovative methods, RACSMEI will generate actionable evidence for public-health authorities, support precision One Health interventions, and help reduce disease burden in affected communities. The project also aims to ensure the transferability of methods and insights to other countries facing similar challenges.

Key Dates

Start date
Dec 18, 2025
Status verified
Jan 2025
Primary completion
Apr 16, 2026
Completion
Sep 30, 2027

Study Design

Enrollment
10,000 participants (estimated)

Arms

  • Arm: Human Community Cohort (National Population Sample)
    Probability-based, multi-stage population sample of \~10,000 participants (2-75 years old) recruited across urban and rural communities nationwide. Data include standardized questionnaires (demography, health conditions, mobility, animal contact, healthcare access) and serum biospecimens for multiplex serology;

Primary Outcome Measure

Seroprevalence of antibodies against an established panel of priority pathogens in the surveyed human populations: [ Time Frame: At the time of blood sampling during household visits, over the inclusion period from December 2025 to April 2026. ]

Central Contacts

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