Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance

Sponsor
University Hospital Ostrava
Study ID
NCT07365046
Status
Not Yet Recruiting

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Conditions

  • Chronic Cough
  • Dysphagia
  • Extraesophageal Reflux
  • Laryngopharyngeal Reflux

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • High resolution oesophageal manometry with impedance — DIAGNOSTIC_TEST
    Patients with extraoesophageal reflux and dysphagia will undergo high resolution oesophageal manometry with impedance.
  • 24-hour pH metry — DIAGNOSTIC_TEST
    Patients with extraoesophageal reflux will undergo 24-hour pH-metry.

Study Details

The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution manometry with impedance and 24-hour pH-impedance monitoring.

Key Dates

First listed
Jan 23, 2026
Start date
Jan 31, 2026
Status verified
Jan 2026
Primary completion
Jun 30, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
160 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Extraoesophageal reflux
    Patients with extraoesophageal reflux will be enrolled in this study arm.
  • Experimental: Dysphagia
    Patients with dysphagia reflux will be enrolled in this study arm.

Primary Outcome Measure

PAET (Proximal Acid Exposure Time) [ Time Frame: 24 hours ]

Central Contacts

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