Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients

Sponsor
University of Alberta
Study ID
NCT07365111
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury
  • Continuous Renal Replacement Therapy (CRRT)
  • Critical Illness
  • Renal Dialysis

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • continuous renal replacement therapy — DEVICE
    We will include any critically ill patient admitted to an intensive care unit requiring dialysis

Study Details

This is a multinational, prospective, observational study designed to characterize patient demographics, prescription parameters, and process measures of continuous renal replacement therapy (CRRT) in intensive care units (ICUs) worldwide. The study aims to examine similarities and differences in CRRT practices and outcomes among critically ill adult patients across a global network of medical centers. The goal is to develop a large, comprehensive repository of data on CRRT practices and outcomes. This repository will enable characterization of variation in standard CRRT practices across medical centers. Natural variability in practice patterns-both between and within centers-will provide an opportunity to compare outcomes associated with different approaches and to generate high-quality preliminary data to inform future interventional trials. Primary Objective \- To describe global patient characteristics, CRRT modalities, and clinical outcomes among patients receiving CRRT. Secondary Objectives * To compare clinical outcomes across geographic regions and CRRT modalities. * To identify patient-level and practice-level predictors of outcomes. * To assess the impact of comorbid conditions (e.g., diabetes mellitus) on CRRT outcomes. Exploratory Objectives * To evaluate long-term renal outcomes and patient-reported quality of life. * To explore health economics and resource utilization related to CRRT. Study Population All patients receiving CRRT as part of routine clinical care in the ICU at participating centers will be eligible for inclusion. Data Collection The study will support an epidemiological assessment of patients undergoing CRRT, including, but not limited to, demographics, underlying disease states, severity of illness, physiological support, indications for CRRT, and clinical outcomes. Outcomes of interest include ICU and hospital mortality, ICU and hospital length of stay, and renal recovery.

Key Dates

First listed
Jan 26, 2026
Start date
Jul 1, 2026
Status verified
May 2026
Primary completion
Mar 31, 2036
Completion
Dec 31, 2036

Study Design

Enrollment
100,000 participants (estimated)

Arms

  • Arm: Patients
    Any patients admitted to the ICU and required CRRT

Primary Outcome Measure

Mortality [ Time Frame: Up to 28 days ]

Central Contacts

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