Exercise, Chronotype, and Prediabetes

Sponsor
German Diabetes Center
Study ID
NCT07389005
Status
Not Yet Recruiting

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Conditions

  • Overweight , Obesity
  • Prediabetes

Eligibility Criteria

Sex
ALL
Age
19 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Timing of exercise — BEHAVIORAL
    An acute exercise bout of cycling performed in the morning at 9 AM
  • Timing of exercise — BEHAVIORAL
    An acute exercise bout of cycling performed in the morning at at 5 PM
  • Control — BEHAVIORAL
    No exercise

Study Details

The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes. The main question it aims to answer is whether doing a single session of exercise in the morning or in the evening affects how the body handles sugar differently in adults with prediabetes who have an extreme natural body clock. This will be done by comparing three conditions (no-exercise, morning exercise, and evening exercise) within the same participant. Each condition will be tested on a different day, with at least 14 days between the test days. During the no-exercise test days, participants will come to the study centre and will only be allowed to do sedentary activities (e.g. office work, reading, or screen time). During the morning exercise test days, participants will perform an exercise session at 9:00 am that involves short periods of very hard effort followed by short rest periods. Whereas for the evening exercise test days, the same type of exercise will be performed at 5:00 pm.

Key Dates

First listed
Feb 5, 2026
Start date
Feb 28, 2026
Status verified
Jan 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: AM exercise
    Behavioral: Timing of exercise
  • Experimental: PM exercise
    Behavioral: Timing of exercise
  • Active Comparator: Control
    Behavioral: Control

Primary Outcome Measure

Insulin sensitivity [ Time Frame: 12 to 24 hours post-exercise intervention ]

Central Contacts

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