Impact of New Hormone Replacement Therapy After Menopause on Heart Health in Women

Sponsor
Heinrich-Heine University, Duesseldorf
Study ID
NCT07394049
Status
Not Yet Recruiting

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Conditions

  • Cardiovascular Diseases
  • Hormone Replacement Therapy
  • Hormone Replacement Therapy, Post-Menopausal
  • Menopause

Eligibility Criteria

Sex
FEMALE
Age
45 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women."

Key Dates

First listed
Feb 6, 2026
Start date
Mar 1, 2026
Status verified
Feb 2026
Primary completion
Mar 31, 2035
Completion
Mar 31, 2035

Study Design

Enrollment
2,725 participants (estimated)

Arms

  • Arm: Post menopausal women with hormone replacement therapy
    Postmenopausal women who have been in menopause and have taken any hormone replacement therapy (HRT).
  • Arm: Post menopausal women without hormone replacement therapy (Control)
    Postmenopausal women who have been in menopause and have not taken any hormone replacement therapy (HRT) These participants serve as the control cohort to compare outcomes against those receiving HRT.

Primary Outcome Measure

MACCE [ Time Frame: 10 years ]

Central Contacts

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