KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

Part of paid clinical trials in Los Angeles, California.

Sponsor
Kumquat Biosciences Inc.
Study ID
NCT07406633
Phase
PHASE2
Status
Recruiting
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Conditions

  • GIST
  • GIST - Gastrointestinal Stromal Tumor
  • GIST Metastatic Cancer
  • Gastro Intestinal Stromal Tumour
  • Gastrointestinal Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • KQB198 — DRUG
    Oral KQB198
  • Imatinib (Gleevec) — DRUG
    Oral Imatinib

Study Details

This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST. Imatinib has been approved by the FDA for the treatment of different types of cancer including GIST.

Key Dates

First listed
Feb 12, 2026
Start date
Jun 30, 2026
Status verified
Jul 2026
Primary completion
Oct 31, 2027
Completion
Oct 31, 2028

Study Design

Enrollment
46 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: KQB198 in Combination with Imatinib

Primary Outcome Measure

Objective response rate (ORR) [ Time Frame: 30 months ]

Central Contacts

Locations (16)

FacilityCityStateZIPSite coordinators
USC Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
Sylvester Comprehensive Cancer CenterMiamiFlorida33136-
Moffitt Cancer CenterTampaFlorida33612-
University of Chicago Medical CenterChicagoIllinois60637-
University of Iowa Health CareIowa CityIowa52242-
Dana-Farber Cancer InstituteBostonMassachusetts02215-
University of Michigan HospitalsAnn ArborMichigan48109-
Mayo Clinic - RochesterRochesterMinnesota55905-
Northwell Health/R.J. Zuckerberg Cancer CenterLake SuccessNew York11042-
University of North Carolina at Chapel HillChapel HillNorth Carolina27599-
Cleveland ClinicClevelandOhio44195-
Oregon Health & Science UniversityPortlandOregon97239-
UT MD Anderson Cancer CenterHoustonTexas77030-
Huntsman Cancer InstituteSalt Lake CityUtah84112-
Fred Hutchinson Cancer CenterSeattleWashington98109-

Find similar trials in Los Angeles, CA

By research site
USC Norris Comprehensive Cancer Center· Los Angeles, CAMayo Clinic - Jacksonville· Jacksonville, FLSylvester Comprehensive Cancer Center· Miami, FLMoffitt Cancer Center· Tampa, FLUniversity of Chicago Medical Center· Chicago, ILUniversity of Iowa Health Care· Iowa City, IA

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