Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.

Sponsor
São Paulo State University
Study ID
NCT07407699
Status
Not Yet Recruiting

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Conditions

  • Chronic Pain
  • Insulin Resistance
  • Postmenopausal

Eligibility Criteria

Sex
FEMALE
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Combined Exercise Program — BEHAVIORAL
    Participants allocated to the intervention group will take part in a supervised combined exercise program, performed twice weekly for 12 months. Each session will last approximately 60 minutes and will include aerobic exercise, resistance training, and mind-body exercise. Aerobic training will consist of walking or cycling at moderate intensity, monitored by heart rate. Resistance training will involve multi-joint exercises using body weight and elastic bands, with progressive overload. Mind-body exercise will be performed using restorative yoga techniques. Exercise sessions will be supervised by a trained physiotherapist.
  • Usual Care Group — OTHER
    Participants allocated to the control group will continue with their usual care and daily activities, without participation in any structured or supervised exercise program during the study period.

Study Details

This study aims to investigate the effects of a combined exercise program on chronic pain in postmenopausal women, considering insulin resistance as a potential physiological mediator. The intervention will assess changes in pain intensity, metabolic and inflammatory biomarkers, psychosocial factors, and body composition. The findings may contribute to understanding the metabolic mechanisms underlying chronic pain in postmenopausal women and support exercise as a non-pharmacological therapeutic strategy.

Key Dates

First listed
Feb 12, 2026
Start date
Aug 31, 2026
Status verified
Feb 2026
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Intervention group
    Postmenopausal women undergoing a supervised combined exercise program (aerobic, resistance, and mind-body exercise).
  • No Intervention: Control Group
    Postmenopausal women who will continue receiving usual care without participation in a structured exercise program during the study period.

Primary Outcome Measure

Pain Intensity [ Time Frame: Baseline and at 12 months following intervention ]

Central Contacts

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