Prospective Twin Pregnancy Cohort at Montpellier University Hospital

Sponsor
University Hospital, Montpellier
Study ID
NCT07408973
Status
Not Yet Recruiting

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Conditions

  • Pregnancy
  • Twin

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biological samples from the mother — OTHER
    During pregnancy, the research team collects: \- 15 ml of urine from the expectant mother. Immediately after delivery, the research team collects: * 10 ml of peripheral blood from the mother * One or two 2 cm x 2 cm pieces of placenta, depending on the type of pregnancy * 12 ml of cord blood for each twin * A 5 cm fragment of cord tissue for each twin
  • Biological samples from the twins — OTHER
    The day after delivery, the reserch team collects: \- A meconium sample from each twin At 6 months and 1 year of age, the parents collect: \- A stool sample from each twin

Study Details

This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development. A total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.

Key Dates

First listed
Feb 13, 2026
Start date
Dec 31, 2026
Status verified
Jun 2026
Primary completion
Mar 1, 2030
Completion
Dec 1, 2030

Study Design

Enrollment
360 participants (estimated)

Arms

  • Arm: Women pregnant with twins
  • Arm: Twins newborns

Primary Outcome Measure

Maternal extern exposome [ Time Frame: From two years before pregnancy until delivery ]

Central Contacts

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