Impact of Thyroid Hormones on Human Glucose and Energy Metabolism

Sponsor
University of Ulm
Study ID
NCT07410637
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Oral Glucose Tolerance Test — OTHER
    Participants will receive a 75 g oral glucose tolerance (3h) before the start of treatment, two weeks and three months after start of treatment. Body composition will measured by bioimpedance analysis. Before and during the oral glucose tolerance test, indirect calometry will assess metabolic flexibility.

Study Details

The goal of this clinical trial to clarify the impact of changes in thyroid hormone levels on glucose and lipid metabolism. Patients will be included in whom thyroid hormone levels are intentionally changed by treatment. In patients with Graves' disease, thyroid hormone levels will be lowered using medication, while in patients with thyroid cancer, thyroid hormone levels will be raised using medication. Oral glucose tolerance tests will be performed before treatment and at two time points after treatment begins to assess metabolic effects.

Key Dates

Start date
Feb 4, 2026
Status verified
Feb 2026
Primary completion
Feb 28, 2031
Completion
Jun 30, 2031

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Phenotyping Cohort
    Patients with Graves' disease and patients with thyroid carcinoma undergoing standard-of-care thyroid treatment.

Primary Outcome Measure

Insulin sensitivity [ Time Frame: Baseline, 2 weeks, 3 months ]

Central Contacts

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