Kynurenine Concentrations During Pregnancy in Women With or Without Chronic Kidney Disease - A Prospective Multicenter Study

Sponsor
CHU de Reims
Study ID
NCT07411937
Status
Not Yet Recruiting

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Conditions

  • Chronic Kidney Diseases
  • Preeclampsia
  • Pregnancy

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood sampling — OTHER
    A 14ml blood sample will be collected during the first second and third trimesters of pregnancy and at 2 months (+ 1 month post partum)

Study Details

Chronic kidney disease (CKD) affects more than 10% of the population worldwide and represents the second most important risk factor for preeclampsia, a life-threatening complication of pregnancy responsible for approximately 80,000 maternal and 500,000 perinatal deaths each year. Experimental studies have suggested a causal link between CKD, relative kynurenine deficiency during pregnancy, and preeclampsia development. Kynurenine, a tryptophan metabolite, plays a central role at the materno-fetal interface, supporting placental energy production, maternal-fetal immune tolerance, and placental perfusion. This study will prospectively assess and compare longitudinal kynurenine concentrations in pregnant women with and without CKD, and evaluate their associations with maternal and fetal outcomes.

Key Dates

First listed
Feb 17, 2026
Start date
Mar 31, 2026
Status verified
Jan 2026
Primary completion
Sep 30, 2028
Completion
May 31, 2029

Study Design

Enrollment
204 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Women with chronic kidney disease
  • Other: Women without chronic kidney disease

Primary Outcome Measure

Kynurenine concentration at the 3rd trimester (32±1 weeks) in women with and without CKD [ Time Frame: 32±1 weeks ]

Central Contacts

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