Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates

Sponsor
Izmir Bakircay University
Study ID
NCT07414095
Status
Recruiting
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Conditions

  • Cirrhosis
  • End-Stage Liver Disease
  • Liver Transplantation

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Comprehensive Observational Assessment in Liver Transplant Candidates — OTHER
    This study involves a comprehensive, multidimensional assessment of liver transplant candidates focusing on frailty, sarcopenia, malnutrition, and psychosocial status. Frailty will be measured using the Liver Frailty Index (LFI), 6-Minute Walk Test (6MWT), Karnofsky Performance Status (KPS), and Activities of Daily Living (ADL). Sarcopenia will be evaluated through handgrip strength, Appendicular Skeletal Muscle Mass (ASM)/Skeletal Muscle Index (SMI), and 4-meter gait speed. Malnutrition will be assessed using the Nutritional Risk Index (NRI) and phase angle derived from bioelectrical impedance analysis. Psychosocial status will be measured with the Hospital Anxiety and Depression Scale (HADS). Clinical parameters (MELD-Na, Child-Pugh, CKI-OKN) will be recorded. Post-transplant adverse outcomes including prolonged hospital and ICU stay, postoperative complications, early mortality, and duration of mechanical ventilation will be monitored up to 30 days after surgery.

Study Details

This study will evaluate frailty, nutrition, sarcopenia, and psychological health in people waiting for a liver transplant. The purpose is to understand how these factors affect outcomes before and after transplantation. By identifying patients at higher risk early, the study aims to support the development of better care programs in the future. Participants will complete simple tests of physical strength, walking speed, and daily activity levels. Their nutrition and psychological well-being will also be assessed. The study will then look at how these results relate to medical scores used in liver disease and to outcomes after transplant, such as hospital stay, complications, or survival. Adults aged 18-65 years who are on the liver transplant waiting list and can understand Turkish are eligible to join.

Key Dates

First listed
Feb 17, 2026
Start date
Dec 15, 2025
Status verified
Feb 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Adult Liver Transplant Candidates
    This cohort includes adult patients (aged 18-65 years) who are on the liver transplant waiting list and able to understand Turkish. Participants will undergo assessments of frailty, sarcopenia, malnutrition, and psychosocial health. No therapeutic intervention will be applied; this is an observational study. Clinical outcomes after transplantation, such as length of ICU stay, hospital discharge time, complications, and survival, will be recorded prospectively.

Primary Outcome Measure

Liver Frailty Index (LFI) [ Time Frame: At hospital admission when liver transplantation is confirmed. ]

Central Contacts

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