Older Kidney Patient Optimisation Pretransplant

Sponsor
Guy's and St Thomas' NHS Foundation Trust
Study ID
NCT07419945
Status
Not Yet Recruiting

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Conditions

  • Cognitive Impairment
  • End Stage Kidney Disease (ESRD)
  • Frailty
  • Health Inequity
  • Kidney Disease
  • Kidney Failure
  • Kidney Transplant
  • Multimorbidity

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Kidney transplant-specific comprehensive geriatric assessment — OTHER
    KT-CGA is an adaptation of the standard Comprehensive Geriatric Assessment (CGA), a multidimensional, interdisciplinary evaluation designed to identify and address medical, functional, psychological, and social factors that influence outcomes in older adults. Like conventional CGA, KT-CGA includes structured assessments of frailty, cognition, mood, mobility, activities of daily living, comorbidity, and social support. KT-CGA incorporates elements specific to advanced kidney disease and transplantation, including review of renal history, dialysis modality, and suitability for renal replacement therapies. It emphasises optimisation: medication reconciliation, health promotion, and onward referral to relevant specialties or allied health professionals as indicated. It is delivered in the outpatient setting by an experienced renal clinician with oversight from a consultant geriatrician trained in perioperative CGA and a consultant nephrologist.

Study Details

The goal of this clinical trial is to learn if a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve the way older adults are assessed for kidney transplantation. The main questions it aims to answer are: Is it feasible and acceptable to deliver a KT-CGA alongside routine transplant assessment in older adults with advanced kidney disease? What is the effect of KT-CGA on decision-making about transplant listing and on patient-reported outcomes such as quality of life and frailty? Researchers will compare participants who receive the KT-CGA plus usual care to those who receive usual care alone. Participants will: Continue with their usual transplant assessment process If randomised to the intervention group, also complete the KT-CGA (a structured set of questionnaires, short memory and function tests, and discussions about wellbeing and support needs, taking about 45-60 minutes)

Key Dates

First listed
Feb 19, 2026
Start date
Feb 2, 2026
Status verified
Feb 2026
Primary completion
Feb 2, 2027
Completion
Feb 2, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Kidney transplant-specific CGA
    This arm will receive KT-CGA (single clinic visit lasting 45-60 minutes with multidimensional assessment of frailty, multimorbidity, cognition, renal disease/treatment and function).
  • No Intervention: Standard pre-transplant care
    This arm will receive usual pre-transplant evaluation and care.

Primary Outcome Measure

Proportion of eligible patients who consented and were randomised [ Time Frame: From first eligible patient approached through completion of recruitment (anticipated 12 months) ]

Central Contacts

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