Effectiveness of Manual Lymphatic Drainage in the Physiotherapeutic Treatment of Migraine

Sponsor
Camilo Jose Cela University
Study ID
NCT07425041
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
20 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Manual lymphatic drainage — OTHER
    Manual lymphatic drainage is a manual therapy technique based on gentle maneuvers that aim to reduce swelling and pain.

Study Details

Migraine is a highly prevalent neurological disorder associated with recurrent headache, disability, and reduced quality of life. In addition to pain, migraine is frequently accompanied by autonomic dysfunction, psychological comorbidities, and sleep disturbances. Manual lymphatic drainage (MLD) is a physiotherapy technique that may influence pain perception and autonomic regulation by promoting lymphatic and venous return and facilitating parasympathetic activity. The aim of this pilot clinical study is to evaluate the effectiveness of manual lymphatic drainage in patients with migraine. Participants will be allocated to an experimental group receiving manual lymphatic drainage or to a control group. Outcomes related to pain intensity, pressure pain thresholds, migraine-related disability, quality of life, psychological variables, sleep quality, and vital signs will be assessed at baseline, after the intervention, and during follow-up periods. This study seeks to provide preliminary evidence on the feasibility and potential clinical effects of manual lymphatic drainage as a non-pharmacological physiotherapy approach for migraine management.

Key Dates

First listed
Feb 20, 2026
Start date
Mar 20, 2026
Status verified
Feb 2026
Primary completion
Apr 20, 2026
Completion
Aug 1, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental group
    This group will receive manual lymphatic drainage sessions for the treatment of migraine.
  • No Intervention: Control group
    This group will serve as a control and will not receive manual lymphatic drainage sessions.

Primary Outcome Measure

Pain intensity (Visual Analogue Scale, VAS) [ Time Frame: Baseline (pre-intervention), immediately post-intervention (after session 6; 3 weeks), 15-day follow-up, and 1-month follow-up. ]

Central Contacts

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