Migraine Clinical Trials

Recruiting migraine studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat migraine. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting migraine studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting migraine trials

Within

Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial

for Migraine

1 site in Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06170281

Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain

for Migraine

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 17

Code: NCT07513662

Tear Biomarkers for Migraine

for Migraine

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07690696

Study to Assess Effectiveness of Oral Atogepant in Adult Participants For Prevention of Migraine in the United Kingdom

for Migraine

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07690215

The Effects of Physiotherapy in Migraine

for Migraine

Sponsor: Ankara Yildirim Beyazıt University

Sex: All·Age: 18 - 55

Code: NCT07657377

Investigation of Imagery Abilities in Individuals With Migraine

for Migraine

Sponsor: Hacettepe University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07546201

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

for Migraine

114 sites incl. Birmingham

Sponsor: Kallyope Inc.

Sex: All·Age: 18 - 75

Code: NCT07645924·Phase 3

Apply to this trial

Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM)

for Migraine Associated Vertigo

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07655440·Phase 4

A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department

for Migraine

1 site in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07667621·Phase 1

Evaluation of the Migraceutics® Phase-Specific Dietary Supplement Regimen on Quality of Life, Work Productivity, and Biomarkers in Adult Migraineurs: The Migraceutics® START Study

for Migraine

1 site in Lutherville-Timonium

Sponsor: Miracle Wellness LLC

Sex: All·Age: 18 - 65

Code: NCT07634146

EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine

for Migraine Disorders

1 site in Tacoma

Sponsor: Cortex Neurovascular

Sex: All·Age: 18 - 64

Code: NCT07652034

Effect of Osteopathic Intervention on Migraine

for Migraine

Sponsor: Escola Superior de Tecnologia da Saúde do Porto

Sex: All·Age: 18 - 50

Code: NCT07542340

Study of EVO756 in Adults With Migraine

for Migraine

14 sites incl. Los Angeles

Sponsor: Evommune, Inc.

Sex: All·Age: 18 - 64

Code: NCT07616128·Phase 2

Apply to this trial

A Comprehensive Digital Care Program for Migraine Management

for Migraine

1 site in San Francisco

Sponsor: Hinge Health, Inc

Sex: All·Age: 18+

Code: NCT07642414

Apply to this trial

The Effect of Foot Reflexology in Women With Migraine

for Migraine

Sponsor: Karabuk University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07651839

Safety and Efficacy of Middle Meningeal Artery Embolization for the Treatment of Migraine.

for Migraine

Sponsor: The Affiliated Hospital Of Guizhou Medical University

Sex: All·Age: 18 - 80

Code: NCT07633067

Migraine and Endometriosis: The FEMININE Study

for Migraine

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Sex: Female·Age: 18+

Code: NCT07519343

Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.

for Migraine

Sponsor: Bernhard Taxer

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07559565

Efficacy of Anti-IL-6 Treatments on Migraine in Patients Treated With Anti-IL-6 for a Rheumatological Condition

for Migraine

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07598045

Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients

for Migraine

6 sites incl. Walnut Creek

Sponsor: Aspeya, Inc.

Sex: All·Age: 18 - 65

Code: NCT07646613·Phase 2

Apply to this trial

Sleep, Stress and Migraine - an Observational and Training Study

for Migraine

Sponsor: Susanne Wegener

Sex: All·Age: 18 - 65

Code: NCT07573488

Apply to this trial

A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With Migraine

for Migraine

1 site in Kansas City

Sponsor: Children's Mercy Hospital Kansas City

Sex: All·Age: 10 - 16

Code: NCT07454798

Apply to this trial

A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in Healthy Adults

for Migraine

Sponsor: Pfizer

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07594769·Phase 1

Apply to this trial

Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study

for Neck Pain

Sponsor: Bozok University

Sex: All·Age: 18 - 65

Code: NCT07567300

Apply to this trial

Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine

for Migraine

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 80

Code: NCT07223008

Apply to this trial

Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine

for Migraine

Sponsor: Bozok University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07554664

Apply to this trial

A Phase II Study of NB001 for Acute Migraine Treatment

for Migraine

Sponsor: Chinese PLA General Hospital

Sex: All·Age: 18 - 65

Code: NCT07577050·Phase 2

Scapular Muscle Activation and Shoulder Performance in Migraine

for Migraine

Sponsor: Ankara Yildirim Beyazıt University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07656922

Apply to this trial

Headache Prevalence and Phenotype in Myelin Oligodendrocyte Glycoprotein Antibody -Associated Disease (MOGAD)

for MOGAD

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07479212

Pericranial and General Sensitivity in Patients With Primary Headache

for Primary Headache Disorders

Sponsor: Universitat Internacional de Catalunya

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07514208

Effectiveness of Manual Lymphatic Drainage in the Physiotherapeutic Treatment of Migraine

for Migraine

Sponsor: Camilo Jose Cela University

Sex: All·Age: 20 - 55

Code: NCT07425041

Chronology and Sequence of Premonitory Symptoms

for Migraine

Sponsor: University of Roma La Sapienza

Sex: All·Age: 18 - 65

Code: NCT07681466

Apply to this trial

Selective Activation of the Adrenomedullin Receptors in Migraine

for Migraine

Sponsor: Danish Headache Center

Sex: All·Age: 18 - 65

Code: NCT07451769

Tryptophan as a Modulating Factor in the Antimigraine Efficacy of Triptans

for Migraine

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18 - 50

Code: NCT07177885

Apply to this trial

Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine

for Migraine

Sponsor: University of Sao Paulo

Sex: Female·Age: 18 - 48

Code: NCT06716489

Apply to this trial

Filter Lenses for the Prevention of Migraine Attacks

for Migraine

Sponsor: Rune Skovgaard Rasmussen

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06161129

MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Psychoeducation for Adolescents With Migraine

for Migraine

Sponsor: Medical University Innsbruck

Sex: All·Age: 13 - 17

Code: NCT07419607

Apply to this trial

App-Based Migraine Treatment: The Health enSuite Study

for Migraine

Sponsor: IWK Health Centre

Sex: All·Age: 18 - 50

Code: NCT06797076

Multimodal Physiotherapy Intervention for People With Migraine

for Migraine

Sponsor: Hochschule Osnabruck

Sex: All·Age: 18 - 70

Code: NCT07671703

Apply to this trial

Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale

for PFO

Sponsor: Second Xiangya Hospital of Central South University

Sex: All·Age: 18 - 60

Code: NCT07343154

Assessment of the Impact of Headache on the Employee Population of Libbs Pharmaceutical Ltd

for Migraine Headache

Sponsor: Libbs Farmacêutica LTDA

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07295587

Dietary Intervention for Migraine Relief

for Migraine

1 site in Washington D.C.

Sponsor: American University

Sex: All·Age: 18 - 75

Code: NCT07360405

Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks

for Migraine

3 sites incl. Aliso Viejo

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07310290

Apply to this trial

Online Hatha Yoga Program as an Add-On Therapy for Episodic High-Frequency Migraine

for Migraine

Sponsor: University of Seville

Sex: All·Age: 18 - 65

Code: NCT07694063

Apply to this trial

Phase II Trial of PRT-064040 Nasal Spray for the Treatment of Migraine in Adults

for Migraine

Sponsor: Sichuan Purity Pharmaceutical Technology Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07304518·Phase 2

Apply to this trial

Stimulation of External Carotid Artery Circulation

for Migraine

1 site in Galveston

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 18 - 100

Code: NCT07402954

Apply to this trial

Basic Body Awareness Therapy in Individuals With Migraine

for Migraine

Sponsor: Mustafa Kemal University

Sex: All·Age: 18 - 55

Code: NCT07328685

Apply to this trial

Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

for Migraine

1 site in Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06904287·Phase 3

Apply to this trial

App-based Breathing Program for Migraine Relief

for Migraine

1 site in Phoenix

Sponsor: Arizona State University

Sex: All·Age: 18+

Code: NCT07297901

Motor Evoked Potential and Cortical Silent Period in Migraine

for Migraine

Sponsor: Istanbul Gelisim University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07250464

"Personalized Physiotherapy for Migraine: Effects on Pain, Fatigue, and Physical Function"

for Migraine

Sponsor: Hacettepe University

Sex: All·Age: 18 - 55

Code: NCT07261384

Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA)

for Myofascial Trigger Points

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 45+

Code: NCT07347028

Apply to this trial

Evaluation of the Performance of the Doraldo-Castelletti Scale in Supporting the Neurologist's Decision to Refer Migraine Patients to Physiotherapy

for Migraine

Sponsor: Istituto Auxologico Italiano

Sex: All·Age: 18 - 70

Code: NCT07626307

Apply to this trial

Cabergoline for Episodic Migraine

for Migraine

Sponsor: Aarhus University Hospital

Sex: All·Age: 18+

Code: NCT07072910·Phase 2

Apply to this trial

Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment

for Chronic Pain

Sponsor: University of the Fraser Valley

Sex: All·Age: 19 - 75

Code: NCT07143396

Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Preventative Treatment for Migraine

for Migraine

Sponsor: Abilion Medical Systems AB

Sex: All·Age: 18 - 65

Code: NCT07279623

Apply to this trial

Coping Skills for Migraine: A 6-Month Program

for Migraine

Sponsor: Hacettepe University

Sex: All·Age: 18 - 65

Code: NCT07163559

Predictors of GON Blockade Success in Migraine

for Migraine

Sponsor: Başakşehir Çam & Sakura City Hospital

Sex: All·Age: 18 - 65

Code: NCT07170111

Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

for Migraine

1 site in McLean

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07301008·Phase 4

Apply to this trial

Neuropsychological Profile Characterization in Patients With Migraine: Cognitive Functioning and Psychological Variables

for Migraine

Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Sex: All·Age: 18 - 65

Code: NCT07233941

Apply to this trial

Migraine clinical trials — common questions

Are migraine clinical trials free to join?

Yes. Participating in a migraine clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a migraine clinical trial?

Each migraine study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a migraine trial near me?

Use the location controls above. We'll show recruiting migraine trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many migraine trials are recruiting right now?

We're currently tracking roughly 50 recruiting migraine trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Migraine trials by city

Birmingham, AL Cincinnati, OH Huntsville, AL San Francisco, CA Aurora, CO Boston, MA Cleveland, OH Evanston, IL Gainesville, FL

Related specialties

Neurology