F-18 Tetrafluoroborate PET/CT in Differentiated Thyroid Cancer

Sponsor
Ankara University
Study ID
NCT07436455
Status
Recruiting
Apply to this trial

Conditions

  • Differentiated Thyroid Cancer
  • Thyroid Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • F-18-Tetrafluoroborate PET/CT — DIAGNOSTIC_TEST
    F-18-Tetrafluoroborate whole body PET/CT

Study Details

In patients who have undergone surgery for differentiated thyroid cancer and who demonstrate elevated serum Tg and/or ATg levels during follow-up after radioactive iodine therapy, lesion detection is performed using neck ultrasonography, thorax CT, and F-18 FDG PET/CT. Diagnostic whole-body scanning with low-dose I-131 is not routinely recommended in follow-up due to its low sensitivity and specificity. F-18 TFB is a highly specific imaging agent for differentiated thyroid cancer, entering thyroid follicular epithelial cells via the sodium-iodide symporter (NIS), which is expressed on the cell surface and functions through a mechanism similar to that of I-131. As a PET radiotracer, F-18 TFB has been shown to be superior to I-131 in previous studies. The primary aim of this study is to comparatively evaluate the role of F-18 TFB PET/CT versus the standard imaging modality F-18 Fluorodeoxyglucose (FDG) PET/CT in lesion detection in patients with differentiated thyroid cancer who demonstrate elevated serum Tg and/or ATg levels during follow-up after radioactive iodine therapy. The secondary aims are to investigate the factors predicting F-18 TFB PET/CT positivity and to assess the relationship between the semi-quantitative and quantitative parameters derived from F-18 TFB PET/CT and serum thyroglobulin (Tg) and anti-thyroglobulin (ATg) levels.

Key Dates

First listed
Feb 27, 2026
Start date
Nov 1, 2025
Status verified
Feb 2026
Primary completion
Aug 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: F-18-TFB PET/CT arm
    DTC patients who underwent F-18-TFB PET/CT

Primary Outcome Measure

Diagnostic accuracy of F-18-TFB PET/CT [ Time Frame: From enrollment of the first patient, 9 months ]

Central Contacts

Related Studies