Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study

Sponsor
Ukrainian Society of Regional Anesthesia and Pain Therapy
Study ID
NCT07438769
Status
Not Yet Recruiting

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Conditions

  • Burn Scar Pain
  • Combat-Related Burn Injury
  • Neuropathic Pain
  • Scar-Related Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue. This prospective cohort study aims to determine whether early ultrasound features of scars and nerves predict persistent clinically significant scar pain at 3 and 6 months. Ultrasound measures include scar thickness, echogenicity, Power Doppler vascularity, dynamic adhesion (gliding) assessment, and ultrasound signs of nerve involvement ("US-nerve positive"). Clinical outcomes include pain intensity (NRS), neuropathic pain screening (DN4), and functional interference.

Key Dates

First listed
Feb 27, 2026
Start date
Mar 24, 2026
Status verified
Feb 2026
Primary completion
May 23, 2026
Completion
May 23, 2026

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Persistent Scar Pain
    articipants who develop clinically significant persistent scar pain defined as NRS ≥4 during movement or light touch at 3 or 6 months follow-up after burn injury.
  • Arm: No Persistent Scar Pain
    Participants without clinically significant persistent scar pain (NRS \<4 during movement and light touch) at 3 and 6 months follow-up.

Primary Outcome Measure

Persistent clinically significant scar pain [ Time Frame: 3 mounth ]

Central Contacts

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