Acute Sarcopenia in Hospitalized Older Adults

Sponsor
IRCCS San Raffaele
Study ID
NCT07454759
Status
Not Yet Recruiting

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Conditions

  • Sarcopenia
  • Sarcopenia in Elderly

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acute sarcopenia will be defined as the incidence of sarcopenia compared to baseline measurements at recruitment, using the European Working Group on Sarcopenia in older people 2 (EWGSOP2) criteria — DIAGNOSTIC_TEST
    The study procedures include: * Handgrip dynamometry to evaluate muscle strength using a standardized dynamometer. * Bioelectrical impedance analysis (BIA) and ultrasound of the anterior thigh to measure muscle mass. No comparator procedure is foreseen. The regimen includes baseline assessment within 24 hours of admission, repeated evaluations on days 3, 5, 7, 10, and every five days until discharge (on average maximum 20 days after hospital admission), with follow-up visits at 3 and 6 months post-discharge.

Study Details

Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult. Current standard of care lacks systematic strategies for its early detection and risk stratification. This study therefore proposes to combine established clinical and instrumental assessments (handgrip dynamometry, bioelectrical impedance analysis, ultrasound of the anterior thigh) to better characterize the risk factors, and outcomes of acute sarcopenia in hospitalized patients aged 65 years or older. The study hypothesis is that the use of a systematic objective clinical assessments will improve early detection and risk stratification of this condition and the detection of acute sarcopenia related outcomes. This is a prospective observational cohort study that will be conducted in the Emergency Department and Medical Wards of the San Raffaele Hospital. Studies objectives will include: * Determination of the incidence of acute sarcopenia * Identification of clinical and demographic risk factors for acute sarcopenia and relevant clinical outcomes associated with this condition

Key Dates

First listed
Mar 6, 2026
Start date
Jun 1, 2026
Status verified
Feb 2026
Primary completion
May 1, 2027
Completion
May 1, 2027

Study Design

Enrollment
280 participants (estimated)

Arms

  • Arm: Groups: older adults aged 65 years or above, hospitalized for acute medical condition
    Groups: older adults (male and female) aged 65 years or above, hospitalized for acute medical conditions.

Primary Outcome Measure

ACUTE SARCOPENIA INCIDENCE [ Time Frame: Time point(s): baseline (within 24h of admission), days 3, 5, 7, 10, then every 5 days until hospital discharge (on average maximum 20 days after hospital admission). ]

Central Contacts

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