Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract

Sponsor
Military Institute od Medicine National Research Institute
Study ID
NCT07462000
Status
Recruiting
Apply to this trial

Conditions

  • Cataract
  • Primary Open-Angle Glaucoma (POAG)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy — PROCEDURE
    Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.
  • Phacoemulsification With Intraocular Lens Implantation — PROCEDURE
    Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.

Study Details

This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.

Key Dates

First listed
Mar 10, 2026
Start date
Jan 21, 2026
Status verified
Jan 2026
Primary completion
Jan 21, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Glaucoma + Cataract Group
  • Active Comparator: Cataract Control Group

Primary Outcome Measure

IOP [ Time Frame: Through study completion, an average of 1 year ]

Central Contacts

Related Studies