Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk

Sponsor
University of Edinburgh
Study ID
NCT07470216
Status
Not Yet Recruiting

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Conditions

  • Anesthesia
  • Anesthesia Brain Monitoring
  • Anesthesia Depth Monitoring
  • Cognitive Impairment
  • Cognitive Impairment, Mild
  • Cognitive Impairment, Progressive

Eligibility Criteria

Sex
ALL
Age
70 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Montreal Cognitive Assessment — OTHER
    Preoperative and Postoperative MoCA
  • biomarkers — DIAGNOSTIC_TEST
    * Pre-operatively: sample collected at a suitable time of blood draw for routine peri-operative clinical samples or insertion of a peripheral venous cannula as part of routine anaesthetic care after consent and enrollment. This may be in the POPS clinic or on day of admission for surgery or when canulated for anaesthesia. * Immediate post-operative period: sample collected in recovery or on the ward at the first ordered routine blood-draw. * Up to 7 days post-surgery: sample collected on the ward (or last anticipated routine sample). Biomarkers assessed will be a panel linked to brain injury, inflammation, and cognitive impairment in non-ICU populations.

Study Details

Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a person's ability to live independently. The investigators want to find out the best way to study these problems in older patients undergoing surgery. This is a 'feasibility study', which means we are testing the research methods. The investigators want to see if it is possible to ask participants to do memory tests and give blood samples before and after their operation. The investigators are hoping to include around 40 patients over 2 years in this study. The investigators will compare performance in memory (cognitive assessment) findings before and after surgery and link this to data taken from the anaesthetic, including the types of drugs used, duration, brain features from processed electroencephalogram monitoring and standard recommended monitoring. In addition the investigators will link this to blood sample markers of brain health and function (biomarkers). The results of this study will help the investigators plan a much larger study in the future, with the ultimate goal of making surgery safer for the brain.

Key Dates

First listed
Mar 13, 2026
Start date
Jul 1, 2026
Status verified
May 2026
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Perioperative medicine for Older People undergoing Surgery (POPS) clinic patients
    Age \> 70, scheduled for colorectal or urological surgery with expected anaesthesia time over 60 minutes.

Primary Outcome Measure

The proportion of eligible patients who consent to participate and are successfully screened for delayed neurocognitive recovery up to discharge or 7 days, whichever is sooner. [ Time Frame: Participants will be involved within the study from time of consent (expected at their POPS clinic visit) until up to 7-days after surgery or to hospital discharge (whichever is sooner). ]

Central Contacts

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