Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging

Sponsor
University of Edinburgh
Study ID
NCT07472049
Status
Recruiting
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Conditions

  • Chronic Limb Threatening Ischemia
  • Peripheral Arterial Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Whole body [68Ga]DOTATATE PET-CT — RADIATION
    Targeting vascular inflammation
  • Whole body [18F]GP1 PET-CT — RADIATION
    Targeting thrombus activity
  • Whole body [18F]NaF PET-CT — RADIATION
    Targeting vascular microcalcification
  • Whole body CT angiogram — RADIATION
    To determine anatomical and morphological atherosclerotic plaque characteristics

Study Details

The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with symptomatic peripheral arterial disease.

Key Dates

First listed
Mar 16, 2026
Start date
Jul 31, 2025
Status verified
Aug 2025
Primary completion
Jul 31, 2028
Completion
Jul 31, 2029

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Patients with symptomatic peripheral arterial disease

Primary Outcome Measure

Quantification of PET tracer uptake of [68Ga]DOTATATE, [18F]GP1 and [18F]NaF in the symptomatic lower limb(s) [ Time Frame: From baseline imaging until completion imaging at 1 year ]

Central Contacts

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