MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI

Sponsor
Ankara Etlik City Hospital
Study ID
NCT07472452
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury
  • Critical Illness
  • Renal Resistive Index
  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Renal Resistive Index (RRI) Doppler Ultrasound — DIAGNOSTIC_TEST
    Doppler ultrasonography will measure RRI immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48).
  • Urinary TIMP-2 and IGFBP-7 biomarkers — DIAGNOSTIC_TEST
    Urine samples for \[TIMP-2\]\*\[IGFBP-7\] biomarker measurement will be collected immediately after sepsis diagnosis (T0) and 24 hours later (T24).

Study Details

In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.

Key Dates

First listed
Mar 16, 2026
Start date
Mar 30, 2026
Status verified
Mar 2026
Primary completion
Jun 30, 2026
Completion
Jan 30, 2027

Study Design

Enrollment
130 participants (estimated)

Arms

  • Arm: Sepsis ICU Cohort
    Adult patients (≥ 18 years of age) who are admitted to the intensive care unit with sepsis or who are diagnosed with sepsis during their admission and for whom bedside renal Doppler ultrasonography is feasible will be included in the study. Participants' Renal Resistive Index (RRI) measurements will be evaluated immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48). Urinary \[TIMP-2\]\*\[IGFBP-7\] measurements will be taken immediately after sepsis diagnosis (T0) and at 24 hours (T24). Clinical and laboratory data of the patients included in the study will be recorded for up to 72 hours after sepsis diagnosis. No treatment will be administered to the patients by the researchers; all medical care will be provided according to standard practice.

Primary Outcome Measure

Renal resistance index (RRI) [ Time Frame: Immediately after sepsis diagnosis (T0, baseline, first measurement) ]

Central Contacts

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