Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy

Sponsor
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study ID
NCT07473518
Status
Recruiting
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Conditions

  • Pediatric Cancer
  • Thyroid Carcinoma

Eligibility Criteria

Sex
ALL
Age
10 Years - 43 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.

Key Dates

First listed
Mar 16, 2026
Start date
Jul 30, 2025
Status verified
Dec 2025
Primary completion
Jul 30, 2026
Completion
Jul 30, 2027

Study Design

Enrollment
2,550 participants (estimated)

Primary Outcome Measure

To calculate the incidence of thyroid nodules and/or thyroid cancer in patients who were exposed and not exposed to radiotherapy [ Time Frame: At 4 years after radiotherapy for the radiotherapy-exposed group; At the time of ultrasound for the non-radiotherapy group ]

Central Contacts

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