Plasma Relaxin Measurement Based on Endometrial Preparation for Embryo Transfer

Sponsor
Hospices Civils de Lyon
Study ID
NCT07477340
Status
Not Yet Recruiting

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Conditions

  • Embryos Transfert
  • Infertility

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Relaxine dosage — BIOLOGICAL
    An additionnal 5m blood sample will be taken during the current blood sample at the beginning of the pregnancy.

Study Details

Pregnancies achieved through assisted reproductive technology (ART) are associated with more obstetric complications than natural pregnancies. In pregnancies achieved through in vitro fertilization, different obstetric outcomes are observed depending on the type of embryo transfer performed and the type of endometrial preparation. Studies comparing obstetric complications according to the type of transfer performed (fresh or frozen embryo transfer) suggest an increased risk of preeclampsia, fetal macrosomia, and postpartum hemorrhage in pregnancies achieved through frozen embryo transfer. Depending on the endometrial preparation methods used prior to frozen embryo transfer, different obstetric risks are observed. Comparisons mainly focus on stimulated cycles versus natural cycles and spontaneous pregnancies. Pregnancies achieved through frozen embryo transfer in a stimulated cycle are thought to be at greater risk of preeclampsia, fetal macrosomia, and postpartum hemorrhage than natural cycles and spontaneous pregnancies. One of the first markers of this vascular adaptation is the cranio-caudal length (CCL). Indeed, the cranio-caudal length of embryos in the first trimester is a good reflection of embryonic growth and therefore of vascular adaptation in the first trimester of pregnancy. Differences in growth between embryos from fresh transfers, frozen transfers, and spontaneous pregnancies are visible early on, as early as the first trimester. The hypotheses put forward to explain these differences include the secretion of relaxin by the corpus luteum, which is present in the natural cycle but not in the substituted cycle. This hormone plays a role in cardiovascular and renal adaptation to pregnancy in the first trimester. Low levels of relaxin would therefore be associated with poorer cardiorenal adaptation in the first trimester and thus with greater vascular risks in late pregnancy.

Key Dates

First listed
Mar 17, 2026
Start date
May 1, 2026
Status verified
Mar 2026
Primary completion
Feb 1, 2028
Completion
Feb 1, 2028

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Fresh ambryo transfert
  • Arm: Frozen embryo transfert with Follicle stimulating hormone
  • Arm: Frozen embryo transfert with hormonal substitutive treatment cycle

Primary Outcome Measure

Relaxin Level [ Time Frame: Up to 19 weeks ]

Central Contacts

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