Berberine Supplementation, Sprint Interval Training, and Immune Function Study

Part of paid clinical trials in Greeley, Colorado.

Sponsor
University of Northern Colorado
Study ID
NCT07480018
Status
Active Not Recruiting

Conditions

  • Anaerobic Power
  • Berberine
  • Inflammation Biomarkers
  • Monocyte Function
  • Sprint Training
  • Wellbeing

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Berberine — DIETARY_SUPPLEMENT
    Consumption of a commercially-available Berberine supplement at a dosage of 500mg, Three times per day with meals, for a total dosage of 1500mg/day.
  • Placebo — OTHER
    Consumption of placebo capsules composed of rice flour at a dosing of 3 capsules per day with meals.
  • Sprint Interval Training — OTHER
    Multiple sets of maximal effort 30 second sprints, inter spaced with 4 minutes of rest/active recovery, on the cycle ergometer over the course of 6 sessions during the 2-Week intervention. Resistance for each set is calculated at 7.5% of the body mass of the participant. Sets for each session are as follows: (1) 4 Sets, (2) 5 Sets, (3) 6 Sets, (4) 6 Sets, (5) 7 Sets, (6) 4 Sets.

Study Details

The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?

Key Dates

Start date
Jan 1, 2026
Status verified
Mar 2026
Primary completion
May 1, 2026
Completion
Jun 1, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Active Comparator: Berberine Only Group (BO)
    Participants in BO will consume a commercially-available Berberine supplement (500mg, 3x Daily with Meals) for 2-weeks stored in identical vegan capsules and instructed to maintain daily activities and diets.
  • Placebo Comparator: Placebo Only Group (PO)
    Participants in PO will consume placebo capsules (rice flour, 3x Daily with Meals) stored in identical vegan capsules for 2-weeks and instructed to maintain daily activities and diets.
  • Active Comparator: Sprint Interval Training + Berberine Group (SB)
    Participants in SB will consume a commercially-available Berberine supplement (500mg, 3x Daily with Meals) stored in identical vegan capsules and will undergo 6 Sprint Interval Training sessions for 2-weeks.
  • Placebo Comparator: Sprint Interval Training + Placebo Group (SP)
    Participants in SP will consume placebo capsules (rice flour, 3x Daily with Meals) stored in an identical vegan capsules and will undergo 6 Sprint Interval Training sessions for 2-weeks.

Primary Outcome Measure

Monocyte Number [ Time Frame: Visit 1A (Week 0) and Visit 2A (Week 2): 15 minutes for blood draw. The assay itself takes 8 hours. ]

Locations (1)

FacilityCityStateZIP
University of Northern ColoradoGreeleyColorado80631

Find similar trials in Greeley, CO

By research site
University of Northern Colorado· Greeley, CO

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