Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT07488819
Status
Recruiting
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Conditions

  • Alcohol Use Disorder (AUD)
  • Post-Traumatic Stress Disorder, PTSD

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • PF974 — DRUG
    PF974 Radiotracer.

Study Details

Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer \[18F\]PF974

Key Dates

First listed
Mar 23, 2026
Start date
Jul 7, 2025
Status verified
Jun 2026
Primary completion
Mar 1, 2031
Completion
Mar 1, 2032

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: PTSD
    Subjects with Post-Traumatic Stress Disorder
  • Arm: AUD
    Subjects with Alcohol Use Disorder
  • Arm: Healthy Controls (HC)
    Healthy control subjects without AUD or PTSD/Trauma
  • Arm: Trauma Controls (TC)
    Trauma Exposed Healthy Controls without AUD or PTSD

Primary Outcome Measure

Regional [18F]PF974 volume of distribution (VT) [ Time Frame: Once at baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale UniversityNew HavenConnecticut06510
Marc Grasso
[email protected]
2037377074

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By research site
Yale University· New Haven, CT

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