Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT07488819
Status
Recruiting
Apply to this trial

Conditions

  • Alcohol Use Disorder (AUD)
  • Post-Traumatic Stress Disorder, PTSD

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • PF974 — DRUG
    PF974 Radiotracer.

Study Details

Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer \[18F\]PF974

Key Dates

Start date
Jul 7, 2025
Status verified
Jun 2026
Primary completion
Mar 1, 2031
Completion
Mar 1, 2032

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: PTSD
    Subjects with Post-Traumatic Stress Disorder
  • Arm: AUD
    Subjects with Alcohol Use Disorder
  • Arm: Healthy Controls (HC)
    Healthy control subjects without AUD or PTSD/Trauma
  • Arm: Trauma Controls (TC)
    Trauma Exposed Healthy Controls without AUD or PTSD

Primary Outcome Measure

Regional [18F]PF974 volume of distribution (VT) [ Time Frame: Once at baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale UniversityNew HavenConnecticut06510
Marc Grasso
[email protected]
2037377074

Find similar trials in New Haven, CT

By research site
Yale University· New Haven, CT

Related Studies