Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility

Sponsor
Tang-Du Hospital
Study ID
NCT07494877
Status
Recruiting
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Conditions

  • Infertility

Eligibility Criteria

Sex
FEMALE
Age
20 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Routine Anticoagulant Therapy (Aspirin or Heparin Sodium) — DRUG
    Patients receive low-dose aspirin or low molecular weight heparin (e.g., heparin sodium) purely as part of their standard clinical care. The decision to initiate, adjust, or terminate this therapy is made entirely by the attending physician based on clinical indications, strictly independent of this observational study protocol. This is tracked solely as an observational exposure.

Study Details

The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility. Researchers will utilize an ultrasound multimodal system to systematically assess endometrial parameters, including thickness, morphology, peristalsis, and blood flow indices. The study aims to enroll approximately 300 infertile women aged 20 to 45 years. Participants will be observed and grouped based on whether they receive anticoagulant medications, such as aspirin or heparin sodium, as part of their standard clinical care. The study will track ultrasound-based receptivity indicators and follow up on pregnancy status and outcomes at 45 and 90 days of gestation. This study is purely observational, and all clinical treatment decisions are made independently of the study protocol.

Key Dates

First listed
Mar 27, 2026
Start date
Sep 1, 2025
Status verified
Mar 2026
Primary completion
Nov 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Anticoagulant Therapy Cohort
    Patients in this cohort receive routine clinical anticoagulant therapies (such as low-dose aspirin or low molecular weight heparin) in addition to their conventional infertility treatment. The use of anticoagulants is determined by the attending physician based on standard clinical indications, strictly independent of this observational study protocol.
  • Arm: Conventional Treatment Cohort
    Patients in this cohort receive conventional infertility treatment only, without the addition of anticoagulant therapies, as per standard clinical practice.

Primary Outcome Measure

Clinical Pregnancy Rate [ Time Frame: Up to 90 days of gestation ]

Central Contacts

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