Menopause Effects on Cortico-reticular Functioning

Sponsor
University of Jyvaskyla
Study ID
NCT07500922
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
50 Years - 59 Years
Healthy Volunteers
Not accepted

Interventions

  • Physical training — BEHAVIORAL
    A 12-week, 4 x per week (2 x strength and 2 x endurance) training program to be performed voluntarily by the participants after tests at month 2.

Study Details

Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.

Key Dates

First listed
Mar 30, 2026
Start date
Apr 25, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: HRT+training
    The first phase follows the effect of HRT, the second phase follows the effects of HRT+physical training intervention (and compliance to the non-supervised intervention).

Primary Outcome Measure

Short-interval intracortical inhibition (SICI) [ Time Frame: Change from baseline to month 2 and change from baseline to month 5 ]

Central Contacts

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