Membrane Potential Mapping with18F-TPP

Part of paid clinical trials in New Haven, Connecticut.

Sponsor: Yale University
Study ID: NCT07506616
Phase: PHASE1
Status: Recruiting

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Conditions

Membrane Potential Mapping

Eligibility Criteria

Sex: ALL
Age: 21 Years - 80 Years
Healthy Volunteers: Accepted

Interventions

18F-TPP — DRUG
radiotracer specific for imaging mitochondrial membrane potential (ΔΨm) administered intravenously

Study Details

In this study, investigators propose to use PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans.

Key Dates

First listed: Apr 1, 2026
Start date: Aug 31, 2026
Status verified: Sep 2025
Primary completion: Aug 31, 2033
Completion: Aug 31, 2033

Study Design

Enrollment: 24 participants (estimated)
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Arms

Experimental: 18F-TPP
PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans. Each scan may or may not have arterial blood sampling for measurement of the time course of radioactivity in the whole-blood, plasma and radiometabolite analysis on selected plasma samples.

Primary Outcome Measure

Tracers volume of distribution (VT) [ Time Frame: Visit 2 (up to 90 days post screening visit 1) ]

Central Contacts

Shannan Henry
(203) 737-5278
[email protected]
Kristen Torres, BS
203-785-4799
[email protected]

Locations (1)

Facility	City	State	ZIP	Site coordinators
Yale University PET Center	New Haven	Connecticut	06510	-

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By research site

Yale University PET Center· New Haven, CT